If you have diabetes mellitus, your body does not use and store
sugar properly. Over time, diabetes can damage blood vessels in
the retina,
the nerve layer at the back of the eye that senses light and helps
to send images to the brain. The damage to retinal vessels is referred
to as diabetic retinopathy.
NPDR, commonly known as background retinopathy, is an early stage
of diabetic retinopathy. In this stage, tiny blood vessels within
the retina leak blood or fluid. The leaking fluid causes the retina
to swell or to form deposits called exudates.
Many people with diabetes have mild NPDR, which usually does not
affect their vision. When vision is affected, it is the result of
macular edema and/or macular ischemia.
Macular edema is swelling, or thickening, of the macula,
a small area in the center of the retina that allows us to see fine
details clearly. The swelling is caused by fluid leaking from retinal
blood vessels. It is the most common cause of visual loss in diabetes.
Vision loss may be mild to severe, but even in the worst cases,
peripheral (side) vision continues to function. Laser treatment
can be used to help control vision loss from macular edema.
Macular ischemia occurs when small blood vessels (capillaries) close.
Vision blurs because the macula no longer receives sufficient blood
supply to work properly. Unfortunately, there are no effective treatments
for macular ischemia.
In PDR, the retinal blood vessels are so damaged they close off.
In response, the retina grows new, fragile blood vessels. Unfortunately,
these new blood vessels are abnormal and grow on the surface of
the retina, so they do not supply the retina with blood.
Occasionally, these new blood vessels leak and cause a vitreous
hemorrhage. Blood in the vitreous, the clear gel-like substance
that fills the inside of the eye, blocks light rays from reaching
the retina. A small amount of blood will cause dark floaters, while
a large hemorrhage might block all vision, leaving only light and
dark perception.
The new blood vessels can also cause scar tissue to grow. The scar
tissue shrinks, wrinkling and pulling on the retina and distorting
vision. If the pulling is severe, the macula may detach from its
normal position and cause vision loss.
Laser surgery may be used to shrink the abnormal blood vessels and
reduce the risk of bleeding. The body will usually absorb blood
from a vitreous hemorrhage, but that can take days, months or even
years. If the vitreous hemorrhage does not clear within a reasonable
time, or if a retinal detachment is detected, an operation called
a vitrectomy can be performed. During a vitrectomy, the eye surgeon
removes the hemorrhage and the abnormal blood vessels that caused
the bleeding.
People with PDR sometimes have no symptoms until it is too late
to treat them. The retina may be badly injured before there is any
change in vision. There is considerable evidence to suggest that
rigorous control of blood sugar decreases the chance of developing
serious proliferative diabetic retinopathy.
Because PDR often has no symptoms, if you have any form of diabetes
you should have your eyes examined regularly by your eye doctor.
A medical eye examination is the only way to find changes inside
your eye. If your eye doctor finds diabetic retinopathy, he or she
may order color photographs of the retina or a special test called
fluorescein angiography to find out if you need treatment. In this
test a dye is injected in your arm and photos of your eye are taken
to detect where fluid is leaking.
If you have diabetes, early detection of diabetic retinopathy is
the best protection against loss of vision. You can significantly
lower your risk of vision loss by maintaining strict control of
your blood sugar and having your eyes checked regularly. People
with diabetes should schedule examinations at least once a year.
Pregnant women with diabetes should schedule an appointment in the
first trimester because retinopathy can progress quickly during
pregnancy. More frequent medical eye examinations may be necessary
after the diagnosis of diabetic retinopathy, with the goal of diagnosing
progression of the disease before the vision is affected.
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Eye Diseases